Journal: Hearing research

Article Title: Cochlear implant material effects on inflammatory cell function and foreign body response

doi: 10.1016/j.heares.2022.108597

Figure Lengend Snippet: Intracochlear neo-ossification relative to platinum and PDMS bearing surfaces. 3D X-ray microscopy images of a single chronically implanted mouse cochlea (A,B,C) with the CI imaged in-situ were volumetrically segmented to compare the amount of neo-ossification in 3 separate areas: the area immediately adjacent to platinum electrode surfaces “Electrode” (red), the area adjacent to PDMS surfaces toward the backside of the electrode contact surface “Anti-electrode” (green), and the intracochlear portions basal to the E1 electrode “Non-electrode” (blue). Dashed lines in (A) denote the manual separation of the “Electrode” (red) and “Anti-electrode” (green) areas in which neo-ossification was volumetrically quantified and in (B,C) indicate the basal and apical limits confining the “Electrode” and “Anti-electrode” areas, with the “Non-electrode” area being basal to this area, stopping at the round window. “E1”, “E2” and “E3” denotes electrode contacts 1,2 and 3, respectively; “M” denotes modiolus; “RW” denotes the round window outlined by a red hashed circle in (B,C). The gray and dark yellow shading in (B) represent the open scala tympani space and areas of soft tissue fibrosis without neo-ossification, respectively. Mean quantification of volume of neo-ossification across n = 6 subjects with individual data points noted as dots and error bars representing 1 standard deviation is shown in (D). The greatest volume of neo-ossification was seen in the “Electrode” area immediately adjacent to the Platinum electrodes, followed by the “Anti-electrode” and “Non-electrode” areas, however these differences were not significant (p > 0.05).

Article Snippet: 3D X-ray microscopy data were analyzed in GraphPad Prism software (Graph-Pad Software, USA) via ordinary one-way ANOVA.

Techniques: Microscopy, In Situ, Standard Deviation

Journal: Annals of Cardiothoracic Surgery

Article Title: Changes in aortic root dimensions post aortic root enlargement with Y-incision and modified aortotomy

doi: 10.21037/acs-2024-aae-0042

Figure Lengend Snippet: Representative example with 3D renderings of the aortic root from pre-operative (left) and post-operative (right) CT scans, demonstrating typical changes in the anatomy observed with Y-incision ARE, including significant enlargement of the sinus widths (+11 mm in this case) and STJ with upsizing by three valve sizes (implanted 29 mm Maga Ease). RCA, right coronary artery; LM, left main; 3D, three-dimensional; CT, computed tomography; ARE, aortic root enlargement; STJ, sinotubular junction.

Article Snippet: Measurements were performed by an experienced cardiovascular imager using specialized three-dimensional (3D) analysis software (Vitrea, Vital Images Inc., Product Version 7.14, Minnetonka, MN, USA).

Techniques: Computed Tomography